Causes and Effects of Therapeutic Interventions: a propensity-based approach or: ‘How can individual patient experiences of therapy outcomes help prevent harm to other patients'

September 12 ^th - 15 ^th 2019

Workshop direction: M. Lindquist, I.R. Edwards, R.L. Anjum, U. Moretti

Many have argued that the nearly exclusive reliance on statistical methods and population data cannot provide an optimal medical care for the individual. Frequencies of outcome, numbers needed to treat and statistical averages are important to quantify risk on the overall population level. However, what is crucial to know for the treated patient is the individual propensity to get a certain outcome. For this, we need to understand the causal mechanisms of the drug, the risk factors of the patient, the specific context of the patient and her story about the condition. However, how would a propensity-based medical care work in practice? This is a challenging question, which requires a multi-disciplinary effort, including basic scientists, epidemiologists, clinicians, pharmacists, decision-makers, manufacturers, patients and philosophers.

The aim of this meeting is to draft a trans-disciplinary approach to the following issues:
• How should medical practice and research be organized to best harness useful, individual patient information to improve general medical knowledge?
• Once available as general medical knowledge, how can the information gathered from individual patients with different propensities support treatment decisions for other individual patients.

Timetable

Print timetable

Arrival in Erice. All the invited persons must register in this website inserting their contact details and the details of their flights. The transfer from the airport (Palermo or Trapani) to Erice will be organized by the Ettore Majorana Centre accordingly.

9:00 AM	Welcome, introduction	Marie Lindquist, Ugo Moretti
9:15 AM	Rules of the game	Marie Lindquist
9:30 AM	Presentation of the workshop’s topic and of the two questions we need to address	Ralph Edwards (first general part) Elena Rocca (second part)
9:45 AM	Working group 1 (4 groups)*
11:45 AM	Reporting back
12:30 PM	Conclusion, recommendations
1:00 PM	LUNCH
2:30 PM	Presentation of the points we are going to focus on specifically in the next working group (based on morning discussion)	One of the organisers
2:45 PM	Working group 2 (4 groups)
4:15 PM	COFFEE/TEA BREAK
4:45 PM	Reporting back
5:30 PM	Conclusion, recommendations
6:00 PM	FREE TIME
7:30 PM	DINNER

9:00 AM	Reflections from day 1	Ralph Edwards, Rani Anjum Bruce Hugman
9:30 AM	Short presentation of the 2019 Rocca, Copeland, Edwards paper ‘Pharmacovigilance as Scientific Discovery. An Argument for Trans-Disciplinarity’, as inspiration for the next session	Elena Rocca
9:45 AM	Working group 3 (4 groups)
11:45 AM	Reporting back
12:30 PM	Conclusion, recommendations
1:00 PM	LUNCH
2:30 PM	Process for drafting
2:45 PM	Drafting session 1
4:15 PM	COFFEE/TEA BREAK
4:45 PM	Drafting session 2
5:30 PM	Conclusion, closing of the meeting

Departure. The transfer to the airport (Palermo or Trapani) will be organized by the Ettore Majorana Centre. Meeting point and time for the departure transfer will be displayed on a panel at the E. Majorana Centre in San Rocco hall, according to the information given upon registration.

Documents

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Attendees

RANI LILL ANJUM – CauseHealth and Philosopher at Center for Applied Philosophy of Science, Norwegian University of Life Sciences
JEAN CHRISTOPHE DELUMEAU – UMC collaborator and Head of pharmacovigilance policy strategy at Bayer
IVOR RALPH EDWARDS – UMC
BIRGITTA GRUNDMARK – UMC
TOBIAS GUSTUM LINDSTAD – CauseHealth collaborator and Clinical Psychologist in Oslo, Norway
KAY BRYNJAR HAGEN – CauseHealth collaborator and Senior Consultant at Regional Centre for Morbid Obesity in North Norway
FRANCOIS HOUYEZ – UMC collaborator and Treatment Information and Access Director / Health PolicyAdvisor, EURORDIS (European Organisation for Rare Diseases)
BRUCE HUGMAN – UMC
MARIE LINDQUIST – Director of UMC, Sweden
MATTHEW LOW – CauseHealth collaborator and Lead Clinician for Musculoskeletal Therapy Services at the Christchurch NHS Trust, UK
UGO MORETTI - University of Verona
EUGENIO PACI - retired, Formerly Clinical Epidemiology Unit, ISPRO – Oncological network, prevention and research institute, Florence, Italy
CHRISTINE PRICE – CauseHealth collaborator and person living with chronic pain, UK
ELENA ROCCA – CauseHealth and Researcher of Pharmacology, Biology and Philosophy of Science at Center for Applied Philosophy of Science, Norwegian University of Life Sciences
LOVISA SANDBERG - UMC
RUTH SAVAGE – UMC
PENNY SAWELL – CauseHealth collaborator and Practising osteopath in Hove, UK
ANDERS SUNDSTROEM – UMC collaborator and Epidemiologist and pharmacovigilance leader in Sweden